Bacitracin + Neomycin Sulphate + Sulphacetamide
Indications
Bacitracin + Neomycin Sulphate + Sulphacetamide is used for:
Bacterial skin infections
Adult Dose
Adult:
Topical: Cream/Ointment: Apply 3 times/day.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to aminoglycosides. Pre-existing nerve deafness. Neonates and infants <2 yr.
Precautions
Avoid application in large quantities and prolonged use. Pregnancy and lactation. Liver and renal impairment.
Avoid contact with eyes or mucous membranes
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Bacitracin + Neomycin Sulphate + Sulphacetamide :
>10%
Allergic contact dermatitis (60%)
1-10%
Erythema
Itching
Edema
Local irritation
Stinging
Burning
Mechanism of Action
Neomycin, an aminoglyoside with antimicrobial spectrum similar to gentamicin, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. It is active against many gram-negative aerobes and against some strains of staphylococci.
Bacitracin, on the other hand, inhibits bacterial cell wall synthesis and is active against many gram-positive bacteria (e.g. staphylococci, streptococci, corynebacteria and clostridia) and some gram-negative species (e.g. Neisseria and Haemophilus influenzae). They are often found in combinations in topical preparations as broad spectrum antibacterial agents.
sulfacetamide: Para-aminobenzoic acid (PABA) inhibitor; restricts folic acid synthesis required for bacterial growth