Beclomethasone dipropionate 0.025% + Gentamycin 0.1% Topical

Indications

Beclomethasone dipropionate 0.025% + Gentamycin 0.1% Topical is used for: Corticosteroid responsive dermatoses, Psoriasis, Eczema, Contact dermatitis

Adult Dose

Adult: Apply to the affected area 2-3 times daily.

Child Dose

Child> 1 year: Apply to the affected area 3-4 times daily.

Renal Dose

Administration

Contra Indications

History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, skin rash.

Precautions

Chronic topical corticosteroid therapy may interfere with growth and development in children Prolonged treatment with corticosteroids is associated with Kaposi sarcoma (consider discontinuation of therapy if diagnosed) Discontinue if contact dermatitis occurs; not for use in patients with decreased skin circulation Manifestations of Cushing syndrome, hyperglycemia, or glycosuria occur, especially if occlusive dressings are used Prolonged use may result in bacterial or fungal superinfection; discontinue if super infection develops

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Beclomethasone dipropionate 0.025% + Gentamycin 0.1% Topical : Skin atrophy,Striae,Burning,Dry skin,Erythema folliculitis,Hypertrichosis,Irritation,Miliaria,Vesiculation,Acneform lesions,Pigmentation changes,Allergic contact dermatitis, Erythema, Pruritus

Mechanism of Action

Beclomethasone is a corticosteroid that has anti-inflammatory activity. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes, inhibiting macrophage accumulation in inflamed areas, reducing leukocyte adhesion to capillary endothelium, reducing capillary wall permeability and edema formation, decreasing complement components, antagonizing histamine activity and release of kinin from substrates, and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation Gentamicin is an aminoglycoside that has broad spectrum bactericidal activity; it is active against a wide variety of pathogenic gram-negative and gram-positive bacteria.