Betamethasone + Clioquinol Topical

Indications

Betamethasone + Clioquinol Topical is used for: Eczema, prurigo nodularis, psoriasis, lichen simplex chronicus, lichen planus, seborrhoeic dermatitis, Otitis externa

Adult Dose

Topical Apply 2-3 times a day in to the affected area for 2-4 weeks.

Child Dose

Topical Child > 2 years: Apply 2-3 times a day in to the affected area for 2-4 weeks.

Renal Dose

Administration

This medicine is for external use on the affected areas of skin only. The cream or ointment should be applied thinly to the affected areas of skin. Wash hands thoroughly after applying this medicine, unless the hands are the area being treated.

Contra Indications

Hypersensitivity, Child under 2 years of age, widespread plaque psoriasis, acne, itching around the anus or genitals, fungal infections, such as ringworm, athletes foot or thrush, viral infections, such as cold sores, herpes or chicken pox

Precautions

Prolonged use with occlusive dressings may cause the body to produce lower levels of the hormone cortisol than normal. Caution applying this to the face over a long period of time as it may cause skin thinning, to the eyelids to make sure it does not get into eye as there may be a risk of developing glaucoma or cataracts. Using this for a prolonged period of time there is a possibility of develop a cataract. Cautious using large quantities for a prolonged period or treating a large area of the body. This medicine may be absorbed through the skin and into blood stream which can result in the following symptoms of hypercortisolism developing; stretch marks, the appearance of blood vessels under the surface of skin, increased body hair growth, changes in skin colour, skin thinning, weight gain or rounding of the face (moon face). Prolonged use or use under occlusive dressings may result in damage to the nervous system. Do not use this medicine on a child under 2 years of age.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Betamethasone + Clioquinol Topical : Common (affects less than 1 in 10 people) local skin burning or pain itchy skin Very rare (affects less than 1 in 10,000 people) Use this for a long period of time, or use under an airtight dressing, may cause the following symptoms: stretch marks may develop the appearance of blood vessels under the surface of your skin increased body hair growth changes in skin colour thinning of your skin and it may also damage more easily skin wrinkling skin dryness weight gain / obesity rounding of the face (moon face) hair loss / lack of hair growth / damaged looking hair These are more likely to happen in infants and children.

Mechanism of Action

Betamethasone is a corticosteroid with mainly glucocorticoid activity. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes, inhibiting macrophage accumulation in inflamed areas, reducing leukocyte adhesion to capillary endothelium, reducing capillary wall permeability and edema formation, decreasing complement components, antagonizing histamine activity and release of kinin from substrates, and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Clioquinol is a halogenated hydroxyquinoline with antibacterial and antifungal activity.