Betamethasone + Gentamicin + Tolnaftate Topical
Indications
Betamethasone + Gentamicin + Tolnaftate Topical is used for:
Allergic inflammatory skin disease, skin mycosis (athlete's foot, trichophytia); tinea versicolor; insect bite and skin disease by secondary bacterial infection.
Adult Dose
Topical/Cutaneous
Superficial dermatophyte infections, Allergic inflammatory skin disease
Apply thin film to affected skin areas 2 times daily.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity to any of the ingredients.
Tuberculosis and most viral lesion of the skin, particularly herpes simplex, vaccinia and varicella.
Precautions
Similar effect to systemic steroid therapy may occur in large amount use or long-term therapy by occlusive dressing technique (ODT). Local adverse effect eg, skin atrophy, facial erythema may occur. Manifestations hypersensitivity eg, itching, flare, vesicle and urticaria may occur. Discontinue using if these reactions occur. Do not use in overdosage or ODT in prolonged period of therapy.
Do not use in the eyes.
Discontinue use in case of no improvements or condition worsens; as soon as possible improvements happen.
Use in pregnancy & lactation.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Betamethasone + Gentamicin + Tolnaftate Topical :
Continuous application without interruption may result in local atrophy of the skin, striae and superficial vascular dilation. Rarely, patients may experience local mild burning or irritation.
Topical use of gentamicin may cause ototoxicity and/or nephrotoxicity when applied to large burned areas or for extended periods of time, especially in patients with renal insufficiency or when administered concurrently with other drugs that are potentially ototoxic or nephrotoxic.
Mechanism of Action
Betamethasone dipropionate is a synthetic fluorinated corticosteroid. It is active topically and produces a rapid and sustained response in those inflammatory dermatoses that are normally responsive to topical corticosteroid therapy.
Gentamicin sulfate is a bactericidal antibiotic active against a wide variety of pathogenic gram-negative and gram-positive bacteria.
Tolnaftate is an antifungal which inhibits growth of dermatophytes e.g. Epidermophyton, Microsporum, trichophyton spp, and Malassezia furfur by distorting the hyphae and stopping mycelial growth. It is inactive against Candida spp or bacteria.
At a combination of 3 agents with distinct pharmacological effects, Gentriderm offers superior anti-inflammatory, antipruritic, bactericidal and fungicidal action for treatment of inflammatory and allergic dermatological conditions threatened or complicated by bacterial and/or common fungal infections.