Betamethasone valerate 0.05% Topical
Indications
Betamethasone valerate 0.05% Topical is used for:
Eczema, atopic dermatitis, contact dermatitis, , systemic lupus erythematosus, lichen planus, lichen simplex, psoriasis, prurigo nodularis, plaque psoriasis
Adult Dose
As valerate: Apply sparingly 2-3 times daily.
Cream for moist & ointment for dry surface.
Child Dose
Renal Dose
Administration
Topical Administration
Use medium to very high potency for less than 2 weeks to reduce local and systemic side effects
Use low potency for chronic therapy
Avoid medium to very high potency on face, folds, and groin, because use in these areas can increase steroid absorption
Use lower potency for children (ie, increased BSA/kg, therefore increased systemic absorption)
Contra Indications
Underlying infection, Hypersensitivity, Ophthalmic use
Precautions
Chronic topical corticosteroid therapy may interfere with growth and development in children.
Lactation: It is not known whether topical corticosteroid use could result in sufficient systemic absorption to produce detectable quantities in human milk; use with caution.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Betamethasone valerate 0.05% Topical :
Dermal atrophy, local irritation, folliculitis, hypertrichosis, burning, dry skin, pigmentation changes, HPA suppression (with higher potency used >2 wk)
Mechanism of Action
Betamethasone is a corticosteroid with mainly glucocorticoid activity. It prevents and controls inflammation by controlling the rate of protein synthesis, depressing the migration of polymorphonuclear leukocytes and fibroblasts, and reversing capillary permeability and lysosomal stabilisation.