Calcipotriol topical

Indications

Calcipotriol topical is used for: Mild to moderate plaque psoriasis, Scalp psoriasis

Adult Dose

Topical/Cutaneous Mild to moderate plaque psoriasis Adult: As 0.005% cream/oint: Apply a thin layer and rub in gently and completely to the affected area 1-2 times daily. Max: 100 g/wk; if used together w/ scalp soln, 5 mg of the drug per wk (e.g. cream/oint 60 g w/ scalp soln 40 mL or cream/oint 40 g w/ scalp soln 60 mL). Scalp psoriasis Adult: As 0.005% soln: Apply and rub in gently and completely to the affected area bid. Avoid contact w/ the forehead or uninvolved scalp margin. Max: 60 mL/wk; if used together w/ cream/oint, 5 mg of the drug per wk (e.g. cream/oint 60 g w/ scalp soln 40 mL or cream/oint 40 g w/ scalp soln 60 mL). Hepatic impairment: Severe: Contraindicated.

Child Dose

Topical/Cutaneous Mild to moderate plaque psoriasis Child: As 0.005% oint: Apply bid. Max: 6-12 yr 50 g/wk; >12 yr 75 g/wk. Max duration: 8 wk.

Renal Dose

Renal impairment: Severe: Contraindicated.

Administration

Contra Indications

Hypercalcaemia, Ca metabolism disorder. Acute psoriatic eruptions (scalp soln). Severe renal or hepatic impairment.

Precautions

Patient w/ erythrodermic exfoliative psoriasis, generalised pustular psoriasis. Pregnancy and lactation. Patient Counselling Avoid application to the face, eyes, or mucous membranes. Avoid exposure to natural or artificial sunlight. Monitoring Parameters Monitor serum Ca.

Pregnancy-Lactation

Interactions

Inactivated by salicylic acid externals.

Adverse Effects

Side effects of Calcipotriol topical : Skin irritation, burning, itching, erythema, and dryness; eczema, contact dermatitis, aggravated psoriasis; hypercalcaemia, hypercalciruria. Rarely, skin atrophy, hyperpigmentation, photosensitivity.

Mechanism of Action

Calcipotriol, a synthetic vit D3 derivative, is an antipsoriatic agent. It binds to vit D receptors to induce differentiation and supress proliferation of keratinocytes.