Cefoperazone + Sulbactam

Indications

Cefoperazone + Sulbactam is used for: Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections

Adult Dose

Intravenous Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections Adult: Ratio of sulbactam:cefoperazone is 1:1. Doses are expressed in terms of cefoperazone. Mild to moderate infections: 1-2 g daily, given in equally divided doses every 12 hr. Severe infections: Up to 4 g daily, given in equally divided doses every 12 hr; max dose of sulbactam: 4 g daily.

Child Dose

Intravenous Meningitis, Respiratory tract infections, Skin and soft tissue infections, Intra-abdominal infections, Urinary tract infections, Septicaemia, Bone and joint infections, Gynaecological infections Child: Ratio of sulbactam:cefoperaone is 1:1. Doses are expressed in terms of cefoperazone. Recommended doses: 20-40 mg/kg/day, given in equally divided doses every 6-12 hr. For serious infections: Up to 160 mg/kg/day, given in 2-4 equally divided doses may be used. Max dose of sulbactam: 80 mg/kg/day

Renal Dose

Renal impairment: Dose adjustments may be needed.

Administration

Contra Indications

Hypersensitivity. Known allergy to penicillins.

Precautions

Pregnancy, lactation.

Pregnancy-Lactation

Interactions

With aminoglycosides: Concomitant admin may increase risk of nephrotoxicity. With heparin/warfarin: Concurrent use may cause marked hypoprothrombinemia and/or prolonged bleeding time.

Adverse Effects

Side effects of Cefoperazone + Sulbactam : Rash, skin reactions, fever, eosinophilia, urticaria, and pruritus. Haematological - Slight decreases in Hb conc and haematocrit value. GI effects, diarrhoea or loose stools, nausea, and vomiting. Mild, transient elevations of serum SGOT, SGPT, and alkaline phosphatase concentrations. Renal effects - Transient elevations in BUN and serum creatinine concentrations.

Mechanism of Action

Cefoperazone, a bactericidal antibiotic, inhibits bacterial cell wall synthesis of actively dividing cells by binding to one or more penicillin binding proteins (PBPs). Sulbactam is a beta-lactamase inhibitor and acts primarily by irreversible inactivation of beta-lactamases.