Chlordiazepoxide + Clidinium

Indications

Chlordiazepoxide + Clidinium is used for: Irritable bowel syndrome

Adult Dose

Oral Irritable bowel syndrome Adult: Each capsule containing chlordiazepoxide 5 mg and clidinium 2.5 mg: 1-2 capsule 3-4 times a day, before meals and at bedtime. Elderly: Minimal effective dose.

Child Dose

Safety and efficacy not established

Renal Dose

Administration

Should be taken on an empty stomach. Take ½-1 hr before meals.

Contra Indications

Hypersensitivity Glaucoma Prostatic hypertrophy Benign bladder neck obstruction Severe respiratory depression

Precautions

Driving, hazardous work, elderly, renal disease, hepatic disease, hypertension, CVS disease, ulcerative colitis, hernia, reflux esophagitis, elderly and debilitated, autonomic neuropathy. Lactation: Distributed in breast milk, avoid use; anticholinergic agents are known to inhibit lactation

Pregnancy-Lactation

Interactions

Cimetidine increases T1/2 of chlordiazepoxide. Absorption of chlordiazepoxide enhanced by metoclopramide and aluminum hydroxide. Chlordiazepoxide absorption hindered by Mg trisilicate, morphine and pethidine. Clidinium faces additive anticholinergic effects with antidepressants, quinidine and some antihistamines. Potentially Fatal: Alcohol potentiates chlordiazepoxide and concurrent use of both can be potentially dangerous.

Adverse Effects

Side effects of Chlordiazepoxide + Clidinium : Mouth dryness, blurring, hesitancy and urgency in micturition, constipation, rise in body temperature, heat stroke, tachycardia, mydriasis, headache, nervousness, drowsiness, weakness, nausea, aggression, dependence, mild skin rashes and impaired psychomotor performance. Potentially Fatal: Severe hypersensitive reaction, hemolytic anemia (rarely).

Mechanism of Action

Chlordiazepoxide: Benzodiazepine; depresses all levels of CNS, including limbic and reticular formation, possibly by increasing gamma-aminobutyric acid (GABA) activity, a major inhibitory neurotransmitter Clidinium: Anticholinergic agent; elicits antispasmodic and antisecretory effects on GI tract