Chlorpheniramine + Phenylephrine + Paracetamol
Indications
Chlorpheniramine + Phenylephrine + Paracetamol is used for:
Flu, cold & fever. Control and management of common cold (headache, fever and nasal congestion).
Adult Dose
Oral
Adult: 1-2 tablets every 4-6 hours.
Child Dose
Oral
Children over 12 years: 1 tablet every 4-6 hours.
Renal Dose
Administration
May be taken with or without food.
Contra Indications
Hyperthyroidism, HTN, coronary disease, MAOIs, nephropathy.
Precautions
Cardiac disease, diabetes, glaucoma, impaired kidney or liver function, pregnancy. May impair ability to drive or operate machinery.
Caution is advised when used during pregnancy.
Pregnancy-Lactation
Interactions
Decreased vasopressor effect w/ phenothiazines or α-adrenergic-blocking agents (eg phentolamine). Increased BP w/ MAOIs. Increased CNS depressant effect w/ alcohol & other CNS depressants eg tranquilizers & narcotic analgesics. Counteracts the anticoagulant effect of heparin.
Adverse Effects
Side effects of Chlorpheniramine + Phenylephrine + Paracetamol :
Restlessness, anxiety, nervousness, weakness, dizziness, pain or discomfort in the chest & abdominal area, tremor, resp distress, pallor or blanching of the skin or appearance of goose flesh. HTN, headache, seizures, cerebral hemorrhage, palpitation, paresthesia or vomiting. Drowsiness. Paradoxical excitement in childn.
Mechanism of Action
Paracetamol is a safe and clinically effective analgesic-antipyretic. It relieves headache, muscle and joint pains, generalized malaise and fever often accompanying the common cold, influenza and other respiratory tract infections.
Paracetamol raises the pain threshold to check headache, muscle and joint pains, and general malaise frequently associated with common cold.
Phenylephrine HCl clears obstructed respiratory passages and nasal sinuses due to congestion thereby facilitating drainage and easier breathing.
Phenylpropanolamine HCl provides efficient decongestion of obstructed and inflamed nasal and paranasal mucosa. Compared with ephedrine and phenylephrine which gives a 2-hr long activity, phenylpropanolamine gives a 7-hr duration of decongestive activity. In point of clinical safety, it is less likely to cause central stimulation resulting in anxiety or insomnia. Neither does it cause rebound congestion.
Chlorpheniramine maleate is a well-accepted anti-allergic agent (antihistamine). It relieves allergic manifestations eg, itching, sneezing and runny nose.
Chlorpheniramine maleate is useful for controlling allergic manifestations of upper respiratory afflictions eg, runny nose, postnasal drip, sneezing and lacrimation. Aside from being an effective histamine antagonist, chlorpheniramine maleate acts synergistically with phenylpropanolamine to provide greater decongestive effect and longer relief. And with the improvement of nasal and paranasal drainage, ventilation is not only improved, but secondary infections and complications which may follow blockage are also prevented.