Chlorpheniramine + Pseudoepedrine

Indications

Chlorpheniramine + Pseudoepedrine is used for: Relief of Cold & Fever

Adult Dose

Relief of Cold & Flu Symptoms Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr

Child Dose

Relief of Cold & Fever 6-12 Years Old Chlorpheniramine maleate 2 mg and pseudoephedrine HCl 30 mg PO q4-6hr >12 Years Old Chlorpheniramine maleate 4 mg and pseudoephedrine HCl 60 mg PO q4-6hr

Renal Dose

Administration

Contra Indications

Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; asthma attacks, narrow-angle glaucoma, symptomatic prostate hypertrophy, bladder-neck obstruction, and stenosing peptic ulcer

Precautions

Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine Chlorpheniramine may cause significant confusional symptoms; not for administration to premature or full-term neonates Lactation: enters breastmilk/contraindicated

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chlorpheniramine + Pseudoepedrine : Hypertension,Hypotension,Palpitations,Reflex tachycardia,Severe peripheral and visceral vasoconstriction,Tachycardia,Confusion,Depression,Distress,Dizziness,Excitability,Euphoria,Fatigue,Headache,Insomnia,Irritability,Restlessness,Sedation,Tremor,Anorexia,Agranulocytosis,Hemolytic anemia,Thrombocytopenia,Thickening of bronchial secretions,Wheezing

Mechanism of Action

Chlorpheniramine blocks muscle responses in histamine and acts as an antagonism of the constrictor effects of histamine on respiratory smooth muscle. Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.