Chlorzoxazone + Paracetamol
Indications
Chlorzoxazone + Paracetamol is used for:
Adjunctive therapy for pain relief & muscle spasm associated w/ acute, painful musculoskeletal conditions.
Adult Dose
Adult 1-2 tab qds.
Child Dose
Renal Dose
Administration
Should be taken with food.
Contra Indications
Hypersensitivity
Precautions
Hepatic dysfunction. May affect ability to drive or operate machinery. Pregnancy & lactation.
Pregnancy-Lactation
Interactions
Antipsychotics, CNS depressants, alcohol.
Adverse Effects
Side effects of Chlorzoxazone + Paracetamol :
GI disturbances, drowsiness, dizziness, malaise, overstimulation, rash.
Mechanism of Action
Paracetamol has analgesic and antipyretic effects similar to those of aspirin. However, it has no anti-inflammatory effect and does not share the antirheumatic properties of the salicylates. It is rapidly and practically completely absorbed from the GIT. The concentration in plasma reaches a peak in 30-60 min and the plasma t½ is about 2 hrs after therapeutic doses. It is distributed into most body tissues. It crosses the placenta and is present in breast milk.
Chlorzoxazone is a centrally-acting muscle relaxant. Chlorzoxazone acts primarily at the level of the spinal cord and subcortical areas of the brain where it inhibits multisynaptic reflex arcs involved in producing and maintaining skeletal muscle spasm of varied etiology. Chlorzoxazone is rapidly absorbed from the GIT. It is metabolized to 6-hydroxychlorzoxazone and then eliminated in the urine.