Clobetasol + Gentamicin Topical

Indications

Clobetasol + Gentamicin Topical is used for: Inflammatory Skin infections, Corticosteriod-responsive dermatoses w/ secondary infection

Adult Dose

Topical/Cutaneous Inflammatory Skin infections, Corticosteroid-responsive dermatoses Adult: Cream/Oint: Apply gently to the affected area 2-3 times daily.

Child Dose

Topical/Cutaneous Inflammatory Skin infections, Corticosteroid-responsive dermatoses Child > 12 yrs: Cream/Oint: Apply gently to the affected area 2-3 times daily.

Renal Dose

Administration

Contra Indications

Childn <12 yrs. Long-term treatment of ulcerative conditions, rosacea, pruritus; presence of acute infections. Hypersensitivity.

Precautions

Heart failure, recent myocardial infarction, hypertension; diabetes mellitus; epilepsy; glaucoma; hypothyroidism; hepatic failure, renal impairment; psychoses; childn and elderly. Should not enter eyes.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Clobetasol + Gentamicin Topical : Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura, erythema, pruritus, photosensitivity

Mechanism of Action

Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions. Gentamicin interferes w/ bacterial protein synthesis by binding to 30S and 50S ribosomal subunits resulting in a defective bacterial cell membrane.