Clobetasol + Miconazole + Neomycin Topical
Indications
Clobetasol + Miconazole + Neomycin Topical is used for:
Corticosteriod-responsive dermatoses w/ secondary infection by bacteria & fungus.
Adult Dose
Topical/Cutaneous
Corticosteriod-responsive dermatoses w/ secondary infection
Adult: Cream/Oint: Apply gently to the affected area 2-3 times daily.
Child Dose
Topical/Cutaneous
Severe inflammatory skin disorders
Child: >2 yr: As cream/ointment. Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Childn <12 yrs. Long-term treatment of ulcerative conditions, rosacea, pruritus; presence of acute infections.
Precautions
Glaucoma; hypothyroidism; hepatic failure, renal impairment; psychoses; childn and elderly. Should not enter eyes. Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. If used in psoriasis careful patient supervision is important.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clobetasol + Miconazole + Neomycin Topical :
Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura, erythema, pruritus, photosensitivity, irritation, burning, contact dermatitis.
Mechanism of Action
Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.
Neomycin is an aminoglycoside antibiotic that binds to ribosomal 30S and 50S subunits of susceptible bacteria, thus inhibiting protein synthesis; it also causes misreading of the genetic codes on the mRNA template.