Clobetasol + Miconazole Topical

Indications

Clobetasol + Miconazole Topical is used for: Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection

Adult Dose

Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection Cream: Apply thin layer to affected areas q12hr and rub in gently and completely

Child Dose

Corticosteroid-responsive Dermatoses, Inflammatory Fungal Skin Infection <12 years Safety & efficacy not established >12 years: Cream: Apply thin layer to affected areas q12hr and rub in gently and completely

Renal Dose

Administration

Contra Indications

Childn <12 yrs. Long-term treatment of ulcerative conditions, rosacea, pruritus; It is contraindicated in rosacea, acne vulgaris, perioral dermatitis, primary cutaneous viral infections (eg. herpes simplex, chickenpox). Hypersensitivity to the preparations.

Precautions

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Clobetasol + Miconazole Topical : Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura. Burning, Cracking/fissuring of the skin, Erythema, Folliculitis, Irritation, Numbness, Pruritus, Stinging, Hypopigmentation (high potency topical steroids) Potentially Fatal: Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression, Cushing's syndrome, diabetes and hypertension.

Mechanism of Action

Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions. Corticosteroids decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; and reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation. Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.