Clotrimazole 1% Topical

Indications

Clotrimazole 1% Topical is used for: Skin and nail fungal infections, Tinea pedis, Tinea cruris, Tinea corporis, Candidiasis, Pityriasis versicolor

Adult Dose

Topical/Cutaneous Skin and nail fungal infections: Adult: Apply 2 or 3 times daily. Onychomycosis: for 6 months. Tinea pedis & Dermatomycoses: for 4 weeks.

Child Dose

Tinea Corporis/Tinea Pedis Apply to affected area q12hr for 4 weeks Tinea Cruris >2 years: Apply to affected area q12hr for 2 weeks Candidiasis Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks Tinea Versicolor Gently massage sufficient clotrimazole into affected and surrounding area q12hr; reconsider diagnosis if no improvement after 4 weeks

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Avoid contact with eyes upon topical application. Childn <3 yrs. Pregnancy, lactation.If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy category B during 2nd and 3rd trimester; safety in 1st trimester not established

Interactions

Antagonism with polyene antibiotics.

Adverse Effects

Side effects of Clotrimazole 1% Topical : Elevated serum AST (SGOT) concentrations (15%) Topical: Erythema, stinging, irritation; hypersensitivity reactions; contact dermatitis. Edema, Pruritus, Burning, Stinging, Peeling, Urticaria, Skin fissures

Mechanism of Action

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.