Clotrimazole + Selenium Topical
Indications
Clotrimazole + Selenium Topical is used for:
Dandruff, seborrhoic dermatitis of scalp, tinea versicolor.
Adult Dose
Topical/Cutaneous
Seborrhoeic dermatitis; Dandruff
Adult: As shampoo or lotion: Use twice wkly for 2 wk, may repeat at less frequent intervals subsequently.
Topical/Cutaneous
Tinea versicolor
Adult: As lotion: Apply to affected areas, lather w/ a small amount of water and leave on skin for 10 min, then rinse thoroughly. Repeat procedure once daily for 7 days.
Child Dose
Topical/Cutaneous
Seborrhoeic dermatitis; Dandruff
Child: 5-14 yr: Use twice wkly for 2 wk, may repeat at less frequent intervals subsequently.
Renal Dose
Administration
Massage into wet scalp, leave for 2-3 min then rinse thoroughly.
Contra Indications
Hypersensitivity. Broken or severely inflamed skin.
Precautions
Childn. Pregnancy and lactation. Patient Counselling Remove gold, silver and other metallic jewellery prior to use. Avoid use of shampoo w/in 48 hr of applying hair dye, straightening or waving preparations.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clotrimazole + Selenium Topical :
Skin irritation, esp in the genital areas and skin folds; oily scalp, hair discouloration, hair loss.
Mechanism of Action
Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.
Selenium sulfide has antifungal and antiseborrhoeic properties. It is active against Pityrosporum ovale, a yeast-like fungus that is part of the normal flora of the scalp. It also has a cytostatic effect on cells of the epidermis and follicular epithelium, thus reducing corneocyte production.