Diphtheria + Tetanus + Pertussis Vaccine
Indications
Diphtheria + Tetanus + Pertussis Vaccine is used for:
Active immunisation against diphtheria, tetanus and pertussis, Prophylaxis of tetanus in wound management
Adult Dose
Intramuscular
Booster immunisation against diphtheria, tetanus and pertussis
Adult: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm, at least 5 years after last dose.
Prophylaxis of tetanus in wound management
Adult: In cases of uncertain or <3 doses of primary immunisation: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm. In cases of >3 doses of primary immunisation: Administer 0.5 mL if >10 years since last dose for minor wounds or if >5 years since last dose for tetanus-prone wounds (e.g. contaminated with dirt, soil or faeces).
Child Dose
Intramuscular
Active immunisation against diphtheria, tetanus and pertussis
Child: >6 weeks to <7 years As primary immunisation: 1st-3rd doses: 0.5 mL at 2, 4 and 6 months of age at 4-8 weeks interval; 4th dose: 0.5 mL at approx 15-20 months of age, at least 6 months after 3rd dose; 5th dose: 0.5 mL at 4-6 years of age. Doses given via deep inj into the anterolateral muscles of the thigh (<6 weeks to <12 months of age) or the deltoid muscles of the upper arm (>12 months to <7 years of age).
Booster immunisation against diphtheria, tetanus and pertussis
Child: >10 years 0.5 mL via deep IM inj into the deltoid muscle of the upper arm, at least 5 years after last dose.
Prophylaxis of tetanus in wound management
Child: >10 years In cases of uncertain or <3 doses of primary immunisation: 0.5 mL via deep IM inj into the deltoid muscle of the upper arm. In cases of >3 doses of primary immunisation: Administer 0.5 mL if >10 years since last dose for minor wounds or if >5 years since last dose for tetanus-prone wounds (e.g. contaminated with dirt, soil or faeces).
Renal Dose
Administration
Contra Indications
Hypersensitivity. History of encephalopathy within 7 days with pertussis vaccine, progressive neurologic disorder (e.g. infantile spasms, uncontrolled or progressive epilepsy).
Precautions
Patient with history of Arthus-type hypersensitivity or Guillain-Barre syndrome with tetanus vaccine, bleeding disorders (e.g. thrombocytopenia), hypotonic-hyporesponsive episode or crying for ≥3 hours within 48 hours or seizures within 3 days with pertussis vaccine altered immunosuppression. Children (with personal or family history of seizures). Pregnancy and lactation. Postpone immunisation in patients with acute infection or severe febrile illness. Monitoring Parameters Monitor for anaphylaxis and signs of syncope for 15 minutes after inj.
Pregnancy-Lactation
Interactions
Decrease effect with immunosuppressive agents (e.g. corticosteroids, antimetabolites).
Adverse Effects
Side effects of Diphtheria + Tetanus + Pertussis Vaccine :
Significant: Syncope, Guillain-Barre syndrome, brachial neuritis; apnoea (premature infants). Gastrointestinal disorders: Nausea, vomiting, diarrhea, abdominal pain. General disorders and administration site conditions: Asthenia, fatigue, malaise, fever, chills, inj site reactions (e.g. pain, oedema, erythema). Metabolism and nutrition disorders: Anorexia. Musculoskeletal and connective tissue disorders: Myalgia, arthralgia. Nervous system disorders: Headache, dizziness, somnolence. Psychiatric disorders: Irritability. Skin and subcutaneous tissue disorders: Rashes.
Potentially Fatal: Hypersensitivity or anaphylaxis reaction.
Mechanism of Action
DTP vaccine, a combination of diphtheria and tetanus toxoids and acellular pertussis adsorbed vaccines, promotes immunity against diphtheria, tetanus and pertussis by inducing specific antibody production.