Dipivefrine Hydrochloride eye prep

Indications

Dipivefrine Hydrochloride eye prep is used for: Ocular hypertension, Open-angle glaucoma

Adult Dose

Ophthalmic Ocular hypertension, Open-angle glaucoma Adult: As hydrochloride: Instil 1 drop of 0.1% soln in the eye/s every 12 hr.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity. Patients with narrow angles, since any pupillary dilatation may cause an attack of angle-closure glaucoma.

Precautions

Aphakic patients; lactation.

Pregnancy-Lactation

Interactions

Additive ocular hypotensive effects with other anti-glaucoma drugs.

Adverse Effects

Side effects of Dipivefrine Hydrochloride eye prep : Ocular hyperaemia, burning, stinging, irritation, follicular conjunctivitis, mydriasis, allergic reactions, adrenochrome deposits in the conjunctiva and cornea, headache, browache and eye pain. Very rarely, tachycardia and hypertension may occur. Potentially Fatal: Generally well tolerated. Side effects fewer when compared to epinephrine drops.

Mechanism of Action

Dipivefrine is a prodrug of adrenaline. It reduces IOP by decreasing aqueous production and by enhancing outflow.