Fluticasone Propionate + Mupirocin Topical
Indications
Fluticasone Propionate + Mupirocin Topical is used for:
Corticosteroid-responsive dermatoses, Secondary skin infections
Adult Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses, Secondary skin infections
Adult: Apply thinly and rub gently to affected area bid for up to 2 wk.
Child Dose
Topical/Cutaneous
Corticosteroid-responsive dermatoses, Secondary skin infections
Child: >3 mth: Apply thinly and rub gently to affected area bid for up to 2 wk.
Renal Dose
Administration
Apply thinly and rub gently to affected area
Contra Indications
Hypersensitivity
Precautions
Patient w/ untreated cutaneous infection, rosacea, acne vulgaris, perioral dermatitis, perianal/genital pruritus, pruritus w/o inflammation. Avoid abrupt withdrawal when switching from systemic to oral or orally inhaled corticosteroid. Moderate to severe hepatic impairment. Childn. Pregnancy and lactation. Monitoring Parameters Monitor hepatic function, ocular changes, growth, possible eosinophilic conditions; signs/symptoms of Candida infection, hypothalamic-pituitary-adrenal (HPA) axis suppression/adrenal insufficiency. Patient w/ extensive burns and wounds.
Pregnancy-Lactation
Interactions
Chloramphenicol may interfere w/ the antibacterial action of mupirocin in RNA synthesis.
Adverse Effects
Side effects of Fluticasone Propionate + Mupirocin Topical :
Burning, stinging, pruritus, pain, rash, erythema, dry skin, tenderness, cellulitis, pain or bleeding secondary to eczema, secondary wound infection, urticaria, swelling, increased exudates, contact dermatitis, furunculosis, exfoliative dermatitis. Rarely, systemic reactions (e.g. nausea, headache, dizziness, abdominal pain, ulcerative stomatitis, systemic allergic reactions).
Mechanism of Action
Fluticasone utilises a fluorocarbothioate ester linkage at the 17 carbon position. It has potent vasoconstrictive and anti-inflammatory activity, but weak hypothalamic-pituitary-adrenal (HPA) inhibitory effect when applied topically.
Mupirocin inhibits protein synthesis of the bacteria by binding to isoleucyl transfer ribonucleic acid (RNA)-synthetase. It has bacteriostatic properties at Min inhibitory concentrations and bactericidal properties at the higher concentrations.