Ibuprofen + Paracetamol
Indications
Ibuprofen + Paracetamol is used for:
Pain and inflammation associated with musculoskeletal and joint disorders
Adult Dose
Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: (Ibuprofen 400 mg + Paracetamol 325/500 mg) 1 tab 3-4 times daily.
Child Dose
Oral
Pain and inflammation associated with musculoskeletal and joint disorders
Child: (Ibuprofen 100mg + Paracetamol 125mg) 1 dose tid or as required.
Renal Dose
Administration
Contra Indications
Active peptic ulcer, history of hypersensitivity to either component, recent GI bleeding, neonates.
Precautions
Bronchial asthma, renal or hepatic disorders, bleeding disorders, CV diseases, hypertension, patients on anticoagulants, aspirin/NSAIDs induced allergy, pregnancy & lactation.
Pregnancy-Lactation
Interactions
Ibuprofen antagonises the effects of furosemide & thiazides. Pethidine & propanthelene reduce absorption of paracetamol. Aspirin displaces ibuprofen from binding sites. NSAIDs blunt the effects of antihypertensives.
Potentially Fatal: Increased risk of GI ulceration & bleeding with anticoagulants. Paracetamol increases the risk of liver damage in chronic alcoholics. Ibuprofen increases the risk of methotrexate toxicity & lithium toxicity.
Adverse Effects
Side effects of Ibuprofen + Paracetamol :
Dyspepsia, heart burn, GI bleeding, rash, asthmatic attacks, thrombocytopenia, drug induced ulcer, drowsiness, hepatic necrosis, renal papillary necrosis, vision disturbances & disorientation; rarely nausea & vomiting can occur.
Potentially Fatal: Hematemesis, agranulocytosis, severe allergic reaction.
Mechanism of Action
Ibuprofen is a potent anti-inflammatory with analgesic and antipyretic action. Its analgesic and antipyretic effects are further reinforced by paracetamol.