Kanamycin

Indications

Kanamycin is used for: Susceptible bacterial Infections

Adult Dose

Susceptible Infections IV Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day divided q6-12hr; administer slowly IM Administration: 5-7.5 mg/kg/dose divided q8-12hr; not to exceed 15 mg/kg/day IM divided q12hr at equally divided intervals; continuously high blood levels are desired; daily dose of 15 mg/kg may be given divided q6-8hr

Child Dose

Renal Dose

Renal Impairment CrCl 50-80 mL/min: give 60-90% of usual dose or give q8-12hr CrCl 10-50 mL/min: give 30-70% of usual dose or give q12hr CrCl <10 mL/min: give 20-30% of usual dose or give q24-48hr

Administration

IV Preparation For adults, IV infusions are prepared by adding 500 mg of kanamycin to 100-200 mL of usual IV infusion fluid such as NS or D5W or by adding 1 g of the drug to 200-400 mL of diluent IV/IM Administration Administer by deep IM injection, or IV infusion May administer by intraperitoneal instillation, irrigation, or inhalation Infuse over 30-60 min

Contra Indications

Hypersensitivity

Precautions

Auditory toxicity more common with kanamycin than with streptomycin and capreomycin; monthly audiometry is recommended while patients are being treated with this drug; vestibular toxicity is rare; renal toxicity occurs at a frequency similar to that of capreomycin; regular monitoring of serum creatinine recommended Renal impairment Myasthenia gravis Vestibular/cochlear implant Nephrotoxic agents

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Kanamycin : Agranulocytosis,Anorexia,Diarrhea,Dyspnea,Edema,Elevated BUN,Enterocolitis,Headache,Incr salivation,Muscle cramps,Muscle weakness,Nausea,Nephrotoxicity,Neurotoxicity,Ototoxicity,Pruritus,Pseudotumor cerebri,Rash,Tinnitus,Thrombocytopenia,Tremor,Vertigo,Weakness

Mechanism of Action

Bactericidal Aminoglycoside contain 1 or 2 amino sugars linked to an aminocyclitol nucleus. Nucleus is 2-deoxystreptamine. Bactericidal and believed to inhibit protein synthesis by binding to 30 S ribosomal subunit.