Lanthanum Carbonate

Indications

Lanthanum Carbonate is used for: Hyperphosphataemia in patients with chronic renal failure

Adult Dose

Oral Hyperphosphataemia in patients with chronic renal failure Adult: As chewable tab/oral powd: Initially, 0.75-2.25 g daily in 3 divided doses. Maintenance dose: 1.5-3 g daily in divided doses. Max: 3.75 g daily. Dose is adjusted every 2-3 wk according to serum phosphate level.

Child Dose

Renal Dose

Administration

Should be taken with food. Take w/ or immediately after meals. Chew thoroughly before swallowing. Do not swallow whole.

Contra Indications

Bowel obstruction, ileus, faecal impaction, hyperphosphataemia.

Precautions

Patient w/ altered GI anatomy (e.g. diverticular disease, peritonitis, history of GI surgery, GI cancer, GI ulceration), hypomotility disorders (e.g. constipation, diabetic gastroparesis), active peptic ulcer, Crohn's disease, ulcerative colitis. Hepatic impairment. Pregnancy and lactation. Patient Counselling This drug may cause dizziness and vertigo, if affected, do not drive or operate machinery. Monitoring Parameters Monitor serum Ca, phosphorus levels.

Pregnancy-Lactation

Interactions

May reduce bioavailability of quinolones, tetracycline and levothyroxine chloroquine, ketoconazole. May decrease serum concentration of ACE inhibitor, ampicillin, halofantrine.

Adverse Effects

Side effects of Lanthanum Carbonate : Significant: GI obstruction, ileus, subileus, GI perforation, faecal impaction. Nervous: Headache, dizziness, vertigo, asthenia, fatigue, malaise. GI: Nausea, vomiting, diarrhoea, abdominal pain, taste alteration, gastroenteritis, constipation, dyspepsia, flatulence, dry mouth, eructation, IBS, anorexia. Endocrine: Hyperglycaemia, hyperparathyroidism. Haematologic: Eosinophilia. Musculoskeletal: Bone deposition, arthralgia, myalgia, osteoporosis. Dermatologic: Alopecia, sweating. Others: Hypocalcaemia, hyperphosphataemia, hypophosphataemia, hypercalcaemia.

Mechanism of Action

Lanthanum forms strong complexes with PO4 that inhibits GI absorption and results in a decrease of serum phosphate and calcium levels