Paracetamol + Methocarbamol

Indications

Paracetamol + Methocarbamol is used for: Spasm & pain associated with acute musculoskeletal disorders. Also tension myalgia, acute traumatic muscle spasm, acute disc prolapse, painful shoulder syndrome. Post-operative joint pain & mechanical low back pain.

Adult Dose

Adult & child over 12 yrs: 1-2 tabs tid;

Child Dose

Child under 12 yrs: not recommended.

Renal Dose

Administration

May be taken w/ meals to reduce GI discomfort.

Contra Indications

Coma or pre-coma states, brain damage, myasthenia gravis Do not admin parenteral solutions in patients with renal impairment, epilepsy or history of epilepsy.

Precautions

Renal or hepatic impairment; acidosis. Pregnancy and lactation. May impair ability to drive or operate machinery.

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Paracetamol + Methocarbamol : Nausea, anorexia, lassitude, drowsiness, dizziness, restlesness, anxiety, confusion, fever, headache, blurred vision, convulsions; hypersensitivity reactions e.g. rashes, pruritus, urticaria, angiodema. Parenteral: Flushing and a metallic taste; incoordination, diplopia, nystagmus, vertigo; sloughing and thrombophloebitis at the site of inj. Thrombocytopenia, leucopenia, pancytopenia, neutropenia, agranulocytosis, pain and burning sensation at inj site. Rarely, hypotension and tachycardia. Potentially Fatal: Parenteral: Syncope, hypotension, bradycardia, anaphylaxis.

Mechanism of Action

Methocarbamol is a centrally acting skeletal muscle relaxant whose precise mode of action is not known. It is said to cause general depression of the central nervous system. Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.