Silodosin

Indications

Silodosin is used for: Treating the signs and symptoms of enlarged prostate (benign prostatic hyperplasia [BPH]).

Adult Dose

Benign Prostatic Hyperplasia Adults PO 8 mg once daily with a meal. Hepatic Impairment Mild-to-moderate impairment (Child-Pugh class A or B): Dose adjustment not necessary Severe Impairment: (Child-Pugh class C): Contraindicated (not studied)

Child Dose

Renal Dose

Renal Impairment CrCl <50 mL/min: Dose adjustment not necessary CrCl 30-50 mL/min: 4 mg PO qDay CrCl <30 mL/min: Contraindicated

Administration

Contra Indications

Hypersensitivity.

Precautions

Impaired hepatic & renal function. Start treatment w/ a low dose (2 mg/dose).

Pregnancy-Lactation

Interactions

Ketoconazole, digoxin.

Adverse Effects

Side effects of Silodosin : >10% Retrograde ejaculation (28%) 1-10% Diarrhea (3%),Headache (2%),Insomnia ((1-2%),Dizziness (3%),Orthostatic hypotension (3%; increased in patients >65 years),Nasopharyngitis (2%),Nasal congestion (2%),Sinusitis (1-2%)

Mechanism of Action

Selectively blocks postsynaptic alpha-1 adrenoreceptors located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra.