Clobetasol + Gentamicin + Miconazole Topical
Indications
Clobetasol + Gentamicin + Miconazole Topical is used for:
Corticosteriod-responsive dermatoses w/ secondary infection by bacteria & fungus.
Adult Dose
Topical/Cutaneous
Corticosteriod-responsive dermatoses w/ secondary infection
Adult: Cream/Oint: Apply gently to the affected area 2-3 times daily.
Child Dose
Corticosteriod-responsive dermatoses w/ secondary infection
Child > 12 yrs: Cream/Oint: Apply gently to the affected area 2-3 times daily.
Renal Dose
Administration
Contra Indications
Hypersensitivity. Childn <12 yrs. Long-term treatment of ulcerative conditions, rosacea, pruritus; presence of acute infections.
Precautions
Glaucoma; hypothyroidism; hepatic failure, renal impairment; psychoses; childn and elderly. Should not enter eyes.
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Clobetasol + Gentamicin + Miconazole Topical :
Perioral dermatitis, striae esp in flexures. Dermal and epidermal atrophy esp on the face, steroid purpura, erythema, pruritus, photosensitivity, irritation, burning, contact dermatitis.
Mechanism of Action
Clobetasol is a very potent corticosteroid used in short-term treatment of various inflammatory skin conditions.
Gentamicin interferes w/ bacterial protein synthesis by binding to 30S and 50S ribosomal subunits resulting in a defective bacterial cell membrane.
Miconazole inhibits ergosterol synthesis thus damaging fungal cell wall membrane and increases its permeability, allowing leakage of nutrients.